Noha is an organic and medicinal chemist working in the field of drug discovery. Her office is TSA149.
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Email
n.ziedan@chester.ac.uk -
Telephone
01244 512 607 -
Facebook
@UoCSciEng -
Twitter
@UoCNatSci
About Dr Noha Ziedan
Noha graduated from the School of Pharmacy in Egypt and obtained her MSc and PhD in the field of Medicinal Chemistry. She worked in teaching and research across a number of universities in Egypt and the UK. She joined the department of Natural Sciences at Chester as a lecturer in June 2018.
Teaching
Noha is teaching the following modules in the BSc Chemistry course:
- SE4026 Chemistry Fundamentals II
- SE5049 Analytical Chemistry
Research
Noha’s main focus of research activity is the discovery and development of novel small active molecules as drug candidates to compact disease with primary interest in cancer research. Her research interests can be divided into the following categories:
- Selective apoptosis induction in cancer cells
- Protein-protein interactions as cancer drug target
- Development of kinesin inhibitors as anticancer agents
Published Work
For a full list of Noha's publications please visit her research profile on google scholar.
Selected publications
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Ziedan, N.I., Hamdy, R., Brancale, A., Jones, A.T., Westwell, A.D. “Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor” Chemical Biology and Drug Design. 2017, 90(1), 147-155.
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Hamdy, R., Ziedan, N.I., Ali, S., Bordoni, C., El-Sadek, M., Lashin, E., Brancale, A., Jones, A.T., Westwell, A.D. “Synthesis and evaluation of 5-(indol-3 yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents” Bioorganic and Medicinal Chemistry Letters 2017, 27(4), 1037-1040.
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Hamdy, R., Ziedan, N.I., Ali, S. El-Sadek, M., Lashin, E., Brancale, A., Jones, AT, and Westwell, AD. “Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents”. Bioorganic and Medicinal Chemistry Letters 2013, 23(8), 2391-2394.
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Tohid, S.F.M., Ziedan, N.I., Stefanelli, F., Fogli, S., & Westwell, A.D. “Synthesis and evaluation of indole-containing 3,5-diaryl isoxazoles as potential antitumour agents”. European Journal of Medicinal Chemistry. 2012, 56, 263-270.
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Ziedan, N.I., Fogli, S., Stefanelli, F., & Westwell, A.D. “Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles”. European Journal of Medicinal Chemistry. 2010, 45, 4523-4530.
Qualifications
- BSc in Pharmacy, Zagazig University, Egypt
- MSc in Medicinal Chemistry, Zagazig University, Egypt
- PhD in Medicinal Chemistry, Cardiff University, U.K.
- Member of the Royal Society of Chemistry
- Member of the British Association of Cancer Research