Dr Jon Power

Lecturer

Chester Medical School
j.power@chester.ac.uk
Dr Jon Power

Following my PhD at the University of Portsmouth in helminth parasitology I had a switch in fields to skeletal biology in 1996 when I joined the Bone Research Group, University of Cambridge. Initially I worked as a laboratory technician specialising in hard tissue histology with my main areas of activity relating to osteoporotic hip fracture. I was promoted to Post-doctoral Research Associate in 2000, remaining in the group till 2011. Later I joined the Orthopaedic Research Unit, University of Cambridge working on ovine models of joint repair before becoming a lecturer at the University of Chester at the end of 2012. 

Following my studies (BSc at the University of Salford and PhD at the University of Portsmouth in collaboration with NIMR, Mill Hill, London) I switched fields joining the Bone Research Group, Department of Medicine, University of Cambridge in 1996 working as a laboratory technician specialising in hard tissue histology. Main areas of study related to osteoporotic hip fracture and was promoted to Post-doctoral Research Associate in 2000, remaining in the group till 2011. Later I joined the Orthopaedic Research Unit, Department of Surgery, University of Cambridge working on ovine models of joint repair before becoming a lecturer at the University of Chester at the end of 2012. 

Jon's teaching at both undergraduate and post graduate levels are mainly in the areas of:-

Histology, Histopathology, Microscopy and Parasitology.

Below is a list of module he teaches on at Chester Medical School:-

MD4002 - Cell Biology

MD4010 - Professional Skills for Life Sciences I

MD5018 - Diagnostics and Therapeutics

MD5027 - Professional Skills for Life Sciences II

MD6034 - Parasitology

MD6029 - Dissertation

MD7100 - Research Dissertation

Main interests include:

  • In situ analysis of bone loss associated with femoral neck fracture in the elderly
  • Investigation of an Ovine model of skeletal under-loading
  • Osteocytes as regulators of bone remodelling
  • The role of osteocytic sclerostin (inhibitor of bone formation) in fracture repair
  • Analysis of joint repair mechanisms in ovine models
  • Helminth Parasitology

Power J, Loveridge N, Kröger H, Parker M, Reeve J. Femoral Neck Cortical Bone and Hip Fracture in Women and Men: a Comparison of Age-adjusted Differences in 112 Cases and Controls. Bone (2018).

Hopper N, Wardale J, Brooks R, Power J, Rushton N, Henson F. Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model.(2015) PLoS One. 10(8): e0133937

Power, J., Taggart, J., Parker, M., Berry, J. L., & Reeve, J. (2014). Bone marrow levels of 25 hydroxy vitamin D are not depressed in cases of hip fracture compared with controls. Cell biochemistry and function, 32(4), 341-343.

Power, J., Hernandez, P., Guehring, H., Getgood, A., & Henson, F. (2014). Intra‐articular injection of rhFGF‐18 improves the healing in microfracture treated chondral defects in an ovine model. Journal of Orthopaedic Research, 32(5), 669-676.

Power J, Hernandez P, Wardale J, Henson FM. (2014).  Alterations in sclerostin protein in lesions of equine osteochondrosis. Vet Rec Open.4;1(1)

Gourion-Arsiquaud S, Lukashova L, Power J, Loveridge N, Reeve J, Boskey AL Fourier Transformed Infra-Red Imaging of Femoral Neck Bone: Reduced Heterogeneity of Mineral:Matrix and Carbonate:Phosphate and more Variable Crystallinity in Treatment-Naïve Fracture Cases compared to Fracture-Free Controls. J Bone Miner Res. 2012, 28 (1) 150-161.

Power J, Doube M, van Bezooijen R, Loveridge N, Reeve J. Osteocyte recruitment declines as the osteon fills in: Interacting effects of osteocytic sclerostin and previous hip fracture on the size of cortical canals in the femoral neck. Bone. 2012 May; 50(5):1107-14.

van Lierop AH, Hamdy NA, Hamersma H, van Bezooijen RL, Power J, Loveridge N, Papapoulos SE. Patients with sclerosteosis and disease carriers: human models of the effect of sclerostin on bone turnover.  J Bone Miner Res. 2011 Dec;26(12):2804-11.

Power J, Poole KE, van Bezooijen R, Doube M, Caballero-Alías AM, Lowik C, Papapoulos S, Reeve J, Loveridge N. Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.  J Bone Miner Res. 2010 Aug;25(8):1867-76.

Thomas CD, Mayhew PM, Power J, Poole KE, Loveridge N, Clement JG, Burgoyne CJ, Reeve J.  Femoral neck trabecular bone: loss with aging and role in preventing fracture.  J Bone Miner Res. 2009 Nov;24(11):1808-18.

Poole KE, Vedi S, Debiram I, Rose C, Power J, Loveridge N, Warburton EA, Reeve J, Compston J.  Bone structure and remodelling in stroke patients: early effects of zoledronate.  Bone. 2009 Apr;44(4):629-33. Epub 2008 Dec 11

Power J., Loveridge, N., Lyon, A., Rushton, N., Parker, M., and Reeve, J. Osteoclastic cortical erosion as a determinant of sub-periosteal osteoblastic bone formation in the femoral neck’s response to BMU imbalance. Effects of stance-related loading and hip fracture.  Osteoporos Int. 2005 Sep;16(9):1049-56.

Loveridge, N., Power, J., Reeve, J and Boyde, A. Bone mineralization density and femoral neck fragility.  Bone; 35 929-941: 2004.

Mayhew, P., Kaptoge, S., Loveridge, N., Power, J., Kroger, HP., Parker, M and Reeve, J. Discrimination between cases of hip fracture and controls is improved by hip structural analysis compared to areal bone mineral density. An ex vivo study of the femoral neck. Bone; 34 (2) 352-61: 2004.

Power, J., Loveridge, N., Lyon, A., Rushton, N., Parker, M., and Reeve, J. Bone Remodelling at the Endocortical Surface of the Human Femoral Neck: A Mechanism for Regional Cortical Thinning in Cases of Hip Fracture.  Journal of Bone and Mineral Research; 18(10) 1775-1780: 2003. 

Power, J, Loveridge, N., Rushton, N., Parker M and Reeve, J. Evidence for Bone Formation on the External 'Periosteal' Surface of the Femoral Neck:  A Comparison of Intracapsular Hip Fracture Cases and Controls.  Osteoporosis International; 14 141-145: 2003.

Jordan, G.R., Loveridge, N., Power, J., Clarke, M.T and Reeve, J. Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation Osteoporosis International;14(2)160-5: 2003. 

Jordan, G.R., Loveridge, N., Bell ,K.L., Power, J., Dickson, G.R., Vedi, S., Rushton, N., Clarke, M.T and Reeve, J. Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis) Bone; 32(1) 86-95: 2003.

Jordan, G.R., Loveridge, N., Power, J., Clarke, M.T., Parker, M. and Reeve, J. The ratio of osteocytic incorporation to bone matrix formation in femoral neck cancellous bone: an enhanced osteoblast work rate in the vicinity of hip osteoarthritis. Calcified Tissue International; 72(3) 190-6: 2003.

Loveridge N, Fletcher S, Power J, Caballero-Alías AM, Das-Gupta V, Rushton N, Parker M, Reeve J, Pitsillides AA. Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls. Bone. 2002 Jun;30(6):866-71.

Power, J., Loveridge, N., Rushton, N., Parker M and Reeve, J.  Osteocyte density in aging subjects is enhanced in bone adjacent to remodeling Haversian systems. Bone; 30 (6) 859-865: 2002.

Power, J, Noble, B. S., Loveridge, N., Bell, K. L., Rushton, N. and Reeve, J.  Osteocyte lacunar occupancy in the femoral neck cortex : An association with cortical remodeling in hip fracture cases and controls. Calcified Tissue International; 69(1) 13-19: 2001.

Crabtree N., Loveridge N., Parker M., Rushton N., Power J., Bell KL., Beck TJ., Reeve J. Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. Journal of Bone and Mineral Research; 16(7)1318-28: 2001.

Jordan, G. R., Loveridge, N., Bell, K. L., Power, J., Rushton, N. and Reeve, J.  Spatial clustering of remodeling osteons in the femoral neck cortex: A cause of weakness in hip fracture? Bone;  26:305-313; 2000.

Bell, K. L., Loveridge, N., Jordan, G., Power, J. and Reeve, J.  Osteonal remodelling and focal weakening of the femoral neck cortex. Journal of Bone and Mineral Research; 15:52: 2000.

Bell, K. L., Loveridge, N., Jordan, G. R., Power, J., Constant, C. R. and Reeve, J.  A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone;  27:297-304: 2000.

Bell, K. L., Loveridge, N., Power, J., Rushton, N. and Reeve, J.  Intracapsular hip fracture: Increased cortical remodeling in the thinned and porous anterior region of the femoral neck. Osteoporosis International; 10:248-257: 1999.

Bell, K. L., Loveridge, N., Power, J., Garrahan, N., Stanton, M., Lunt, M., Meggitt, B. F. and Reeve, J.  Structure of the femoral neck in hip fracture: Cortical bone loss in the inferoanterior to superoposterior axis. Journal of Bone and Mineral Research; 14:111-119: 1999.

Bell, K. L., Loveridge, N., Power, J., Garrahan, N., Meggitt, B. F. and Reeve, J.  Regional differences in cortical porosity in the fractured femoral neck. Bone; 24:57-64: 1999.

Power, J., Harnett, W. and Jenkins, T.  Characterisation of the surface polypeptides of Strongyloides ratti; A comparison of homogonic and heterogonic strains. Helminthology; 68 (1) 57-62: 1994.

BSc in Biological Sciences

PhD (nematode parasitology)

PG cert HE